畜牧兽医学报 ›› 2018, Vol. 49 ›› Issue (2): 231-242.doi: 10.11843/j.issn.0366-6964.2018.02.002

• 综述 • 上一篇    下一篇

鸡支原体对氟喹诺酮类药物的耐药判定标准研究现状

王淑歌, 谷宇锋, 黄玲利, 黄安雄, 王旭, 刘振利, 郝海红*, 袁宗辉*   

  1. 国家兽药残留基准实验室(华中农业大学), 农业部兽药残留检测重点实验室(华中农业大学), 国家兽药安全评价实验室(华中农业大学), 农业部畜禽产品质量安全风险评估实验室(武汉), 武汉 430070
  • 收稿日期:2017-08-15 出版日期:2018-02-23 发布日期:2018-02-23
  • 通讯作者: 郝海红(1981-),女,湖北襄阳人,副教授,博士,E-mail:haohaihong@mail.hzau.edu.cn;袁宗辉(1958-),男,湖北天门人,教授,博士生导师,E-mail:yuan5802@mail.hzau.edu.cn
  • 作者简介:王淑歌(1994-),女,河南汝州人,硕士生,主要从事兽药残留与食品安全研究,E-mail:1955065404@qq.com
  • 基金资助:

    国家重点研究发展计划(2016YFD0501302;2017YFD0501406);国家自然科学基金(31772791);中央高校基本科研基金(2662015PY035);畜禽产品质量安全国家风险评估(GJFP2016008)

Establishment on the Susceptibility Breakpoints Standards for Fluoroquinolones against Mycoplasma gallisepticum in Chickens

WANG Shu-ge, GU Yu-feng, HUANG Ling-li, HUANG An-xiong, WANG Xu, LIU Zhen-li, HAO Hai-hong*, YUAN Zong-hui*   

  1. National Reference Laboratory of Veterinary Drug Residues(HZAU), The Key Laboratory for the Detection of Veterinary Drug Residues of Ministry of Agriculture(HZAU), National Laboratory for Safety Evaluation of Veterinary Drugs(HZAU), Laboratory of Quality & Safety Risk Assessment for Livestock and Poultry Products(Wuhan), Wuhan 430070, China
  • Received:2017-08-15 Online:2018-02-23 Published:2018-02-23

摘要:

随着氟喹诺酮类药物在鸡支原体疾病治疗方面的广泛和不合理应用,鸡支原体对氟喹诺酮类药物的耐药现象越来越严重。为了规范氟喹诺酮类药物在鸡支原体疾病治疗上的应用和在一定程度上减缓耐药现象的产生,有必要制定鸡支原体对氟喹诺酮类药物的耐药标准。本文以耐药判定标准为中心,介绍了其定义和制定流程;阐述了国内外支原体对氟喹诺酮类药物的耐药判定标准的相关研究,包括野生型临界值、药效学临界值和临床临界值的相关研究。最后对当前研究的不足进行反思,并提出了自己的设想,以期为减缓鸡支原体对氟喹诺酮类的耐药提供参考。

Abstract:

With the extensive and unreasonable use of fluoroquinolones in the treatment of Mycoplasma gallisepticum disease, the drug resistance of Mycoplasma on fluoroquinolone becoming more and more serious. In order to regulate the application of fluoroquinolones in the treatment of Mycoplasma disease and to reduce the occurrence of drug resistance to a certain extent, it is necessary to develop the standard of resistance to Mycoplasma gallisepticum on fluoroquinolones. The author introduces the definition and formulation process centered on the criteria for drug resistance, and summarized the related studies on the determination of resistance to fluoroquinolones in Mycoplasma at home and abroad, including wild type Cutoff, PK-PD Cutoff and clinical Cutoff. Finally, the shortcomings of the current researches were reviewed and put forward our own ideas, in order to provide a reference to slow down the resistance of Mycoplasma gallisepticum to fluoroquinolones.

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